Studies on microbial transformation of albendazole by soil fungi
نویسندگان
چکیده
Soil enrichment technique was followed to isolate the fungi capable of performing biotransformation of albendazole. Among the 5 fungi isolated, Aspergillus fumigatus, A. niger and Penicillium chrysogenum could transform albendazole to one metabolite and Fusarium moniliforme could transform albendazole to two metabolites. The transformation was confirmed by HPLC. Based on LC-MS-MS analysis, the metabolites formed were predicted to be albendazole sulfoxide and albendazole sulfone. The results support that the soil enrichment is a promising technique for isolation of fungi with industrial applicability, viz. production of active metabolites from drugs.
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تاریخ انتشار 2009